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Binding of IL-1β by XOMA 052 allows assembly of IL-1 signaling complex. XOMA 052 and control Blocking Ab 5 were immobilized on different flow cells of an SPR sensor surface, and IL-1β, sRI, and sRAcP·Fc fusion protein were injected at the points indicated by arrows 1, 2, and 3, respectively. The extracellular domains of both IL-1RI and IL-1RAcP are able to bind to IL-1β bound by XOMA 052. IL-1β bound by Blocking Ab 5 does not allow complex assembly.
