FIGURE 9.

Phosphorylation of p210 and p72 is Hck-dependent in K562 cells. Signal intensities for the three major NaPP1-sensitive tyrosine phosphoproteins shown in Fig. 8 (p210, p72, and p59) were quantitated from anti-phosphotyrosine immunoblots of three independent K562-Neo, K562-Hck, and K562-Hck-T338M cell populations after treatment with imatinib, NaPP1, or both as described in the legend to Fig. 8. The bar graphs show the -fold changes relative to DMSO-treated K562-Neo control cells of the average phosphotyrosine signal intensities ±S.D. for p210 (Bcr-Abl), p72, and p59 (Hck).