FIGURE 3.

C. trachomatis replicates in HeLa cells silenced for the expression of cPLA₂. A, relative yield of infectious units of L2 was assessed in cells treated with different concentration of the cPLA₂ inhibitor AACOCF3 (left panel), the MEK inhibitor U0126 and HeLa lines stably expressing a cPLA₂ specific shRNA (right panel). B, cPLA2 silenced HeLa cells were infected with L2 and tested for the activation of ERK and COX2. Note normal activation of ERK in the absence of cPLA₂. Error bars indicate one standard deviation from the mean.