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Analysis of PS1-FAD mutants in the Gly33-wt background. Quantification of secreted Aβ from SH-SY5Y cells coexpressing PS1-FAD mutants and SPA4CT-wt. PS1-wt was set as 100%. A, total Aβ levels (mean ± S.E., n = 3–10). B, Aβ40 levels (mean ± S.E., n = 3–10). C, Aβ42 levels (mean ± S.E., n = 3–8). D, Aβ38 levels (mean ± S.E., n = 3–9). Asterisks indicate significant differences to PS1-wt/SPA4CT-wt (*, p < 0.01, **, p < 0,001, one-way ANOVA type Dunnett).
