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. 2010 Apr 25;285(28):21817–21823. doi: 10.1074/jbc.M110.131714

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FIGURE 3. — Disruption of the Class C VPS complex promotes tumor growth and metastasis in Ras^V12 cells. A, quantitative real-time reverse transcription-PCR results indicate that the car mRNA level in third-instar larvae was significantly reduced by RNAi. Actin mRNA levels were used as internal controls. *, p < 0.0001. Error bars indicate S.D. B and C, micrographs of compound eye from control (B) and car^RNAi (C) flies, indicating the pigmentation defect in the car^RNAi eye. D–I, larvae/pupae and dissected cephalic complexes from third-instar larvae with indicated genotypes. Both car^RNAi and vps16A^RNAi cause overgrowth and metastasis of GFP-positive Ras^V12 cells. D, F, and H are in the same magnification. E, G, and I are in the same magnification.