. 2010 Apr 25;285(28):21817–21823. doi: 10.1074/jbc.M110.131714

TABLE 1.

Lysosome dysfunction promotes overgrowth and metastasis of Ras^V12 tumors

Genotype	Tumor overgrowth	Metastasis ratio	p value^a
WT	−	0% (n > 200)	NA^b
Ras^V12	+	0% (n > 200)	NA^b
Ras^V12/dor⁸	+++	100% (n = 38)	0^c
Ras^V12/Met^C107	+++	100% (n = 22)	0^c
Ras^V12/Met^D185	+++	100% (n = 29)	0^c
Ras^V12/dor⁸ + UAS-dor	+	0% (n = 50)	1^c
Ras^V12 + car^RNAi	++	29.8% (n = 57)	0.000001^c
Ras^V12 + vps16A^RNAi	++	34.9% (n = 43)	0.000006^c
Ras^V12 + 10% phosphate-buffered saline	+	0% (n = 44)	NA^b
Ras^V12 + chloroquine	++	16.1% (n = 56)	0.0014^d
Ras^V12 + ethanol	+	0% (n = 60)	NA^b
Ras^V12 + monensin	++	11.8% (n = 51)	0.013^e

^a p value was calculated using Fisher's exact test.

^b NA, not applicable.

^c Compared against Ras^V12.

^d Compared against Ras^V12 + 10% phosphate-buffered saline.

^e Compared against Ras^V12 + monensin. p < 0.05 is considered as a significant difference.