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Muc21/epiglycanin is assumed to have 98 TR of 15 amino acids. Muc21 consists of three exons. Exon I encodes a signal sequence; exon II encodes the end of signal sequence, a TR domain, a neck domain, an SEA-like domain, and a transmembrane (TM) domain; and exon III encodes a cytoplasmic (CYP) domain. Exon I was discovered by 5′-RACE, and the full size of the TR domain was estimated by the results of 5′-RACE, NCBI database analysis, and partial sequencing of Muc21 gene from a BAC clone.
