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. 2010 May 6;285(28):21323–21328. doi: 10.1074/jbc.M110.109157

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Top, effect of 10 μm apocynin (an NADPH oxidase inhibitor) on the stimulatory effect of angiotensin II on O production by rat thick ascending limbs. Rat thick ascending limbs were incubated with 1 nm angiotensin II for 10 min in the presence or absence of apocynin and superoxide production measured. n = 5 per group. Bottom, effect of 1 nm angiotensin II for 10 min on O production by thick ascending limbs isolated from wild-type and p47^phox knock-out mice (p47^phox−/−). n = 4. Ang II, angiotensin II.

Inline graphic — Top, effect of 10 μm apocynin (an NADPH oxidase inhibitor) on the stimulatory effect of angiotensin II on O production by rat thick ascending limbs. Rat thick ascending limbs were incubated with 1 nm angiotensin II for 10 min in the presence or absence of apocynin and superoxide production measured. n = 5 per group. Bottom, effect of 1 nm angiotensin II for 10 min on O production by thick ascending limbs isolated from wild-type and p47^phox knock-out mice (p47^phox−/−). n = 4. Ang II, angiotensin II.