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. 2010 May 7;285(28):21615–21624. doi: 10.1074/jbc.M110.107003

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — MAPK/ERK pathway is involved in PDGF-induced Arc expression. A, pretreatment of rat hippocampal neurons with MEK inhibitor (U0126, 20 μm) for 1 h resulted in inhibition of PDGF-mediated Arc expression is shown. ***, p < 0.001 versus control group; ###, p < 0.001 versus PDGF (20 ng/ml) group. B, dominant-negative (DN) MEK but not the constitutively active (CA) MEK resulted in abrogation of PDGF-mediated Arc expression. ***, p < 0.001 versus control group; ###, p < 0.001 versus PDGF (20 ng/ml) group. C, pretreatment of neurons with the PI3K inhibitor (LY294002, 10 μm) failed to inhibit PDGF-mediated Arc induction. **, p < 0.01 versus control group. D, exposure of rat hippocampal neurons to MEK inhibitor also resulted in abrogation of PDGF-mediated Egr-1 expression. ***, p < 0.001 versus control group; ###, p < 0.001 versus PDGF (20 ng/ml) group. Representative immunoblot and the densitometric analysis from four separate experiments is presented.