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. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: Curr Opin Drug Discov Devel. 2010 Jan;13(1):66–77.

Figure 1.

Figure 1

Pathways to irreversible inhibition of P450 enzymes. Pathways a and b indicate the two metabolic routes to inactivate P450 (red boxes) by MI complex formation (green boxes) or by protein alkylation (blue boxes). The off path metabolites (purple box) are not directly involved in the inactivation of the P450 enzymes. Circulating metabolites (pathway a and b) are able to rebind to the P450 enzymes and are further metabolized to inactivate the P450 enzymes. The deactivated metabolites (pathway b) are dead end products and often detected in vitro.