Table 1.

Results from all combination treatment studies.

	Time to >5% Weight Loss	Overall Weight Loss	Clinical Score	Survival
Study 1 (n=5 or 6)
Combo vs. PBS	P=0.049	P=0.003	P=0.003	P=0.0005
Combo vs. VIG	P=0.82	P=0.06	P=0.006	P=0.005
Study 2 (n=5)
Combo vs. control mAb	P=0.02	P=0.017	P<0.0001	P=0.003
Combo vs. VIG	P=0.15	P=0.98	P=0.01	P=0.49
Study 3 (n=10)
Combo vs. control mAb	P=0.0009	P=0.0006	P<0.0001	P<0.0001
Combo vs. VIG	P=0.07	P=0.04	P=0.06	P=0.03
Combo vs. C12	P=0.34	P=0.16	P=0.42	P=0.22
Combo vs. D67	P=0.19	P=0.051	P=0.16	P=0.036
Study 4 (n=10)
Combo vs. control mAb	P<0.0001	P<0.0001	P<0.0001	P=0.0015
Combo vs. VIG	P=0.0009	P=0.039	P=0.0036	P=0.14
Combo vs. C12	P=0.084	P=0.40	P=0.03	P=0.37
Meta-Analysis
Combo vs. control mAb	P<0.0001	P<0.0001	P<0.0001	P<0.0001
Combo vs. VIG	P=0.0002	P=0.0004	P=0.0006	P=0.0003
Combo vs. C12	P=0.046	P=0.049	P=0.096	P=0.006