Table 4.

Multivariate modeling of major events (Cox regression analysis)

Predictor	Model 1		Model 2		Model 3
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Log CFR	1.15 (1.02–1.30)	0.018	1.13 (1.004–1.27)	0.043	1.14 (1.01–1.29)	0.038
SBP	1.02 (1.005–1.04)	0.011	1.02 (1.004–1.04)	0.012	1.02 (1.001–1.04)	0.035
Log CAD Severity	-		1.68 (0.98–2.88)	0.058	1.61 (0.92–2.81)	0.10
Age	-	-	-	-	1.00 (0.96–1.04)	0.90
Hx Diabetes	-	-	-	-	1.44 (0.65–3.20)	0.37
Ever Smoked	-	-	-	-	1.22 (0.60–2.46)	0.58

CFR=coronary flow reserve; CAD=coronary artery disease; SBP=systolic blood pressure; Hx=history of; HR=hazard ratio; CI=confidence interval.

Notes: When interpreting these tables, the hazard ratios reflect the % change in events for every 0.1 unit increment in the log CFR. Adjusting for one covariate at a time among other variables in Table 1 did not substantially change the relationship between CFR and major adverse outcome.