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Comparison of functional domains between C. elegans GSNL-1 and mammalian gelsolin. (A) Functional domains of C. elegans GSNL-1 identified in this study. (B) Functional domains of mammalian gelsolin were adapted from Sun et al. (2) with modifications based on the following references: severing (8), capping (9, 31), PIP2 binding (32, 33, 36), calcium-sensitive G-actin binding in G1 (37), calcium-insensitive F-actin binding in G2 (31), and calcium-sensitive G-actin binding in G4 (38).
