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Summary of properties of GSNL-1 variants
| GSNL-1 | G1G2G3 | G1G2 | G1b | G1a | G3G4 | |
|---|---|---|---|---|---|---|
| Amino acid sequence | 1-475 | 1-353 | 1-239 | 1-131 | 1-115 | 240-475 |
| Filament severing | ||||||
| +Ca2+ | ++ | ++ | ++ | ++ | + | − |
| −Ca2+ | − | − | − | − | − | − |
| Capping | ||||||
| +Ca2+ | + | + | + | − | − | − |
| −Ca2+ | − | − | − | − | − | − |
| G-actin binding | ||||||
| +Ca2+ | + | + | + | + | + | + |
| −Ca2+ | − | + | − | − | − | + |
| F-actin binding | ||||||
| +Ca2+ | + | + | ± | − | − | + |
| −Ca2+ | − | − | − | − | − | + |
| PIP2 binding | ||||||
| +Ca2+ | + | − | + | − | − | − |
| −Ca2+ | + | − | + | ± | − | − |
| PIP2 regulation | ||||||
| +Ca2+ | ++ | + | ++ | + | + | ND |
