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. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: Drug Metab Pharmacokinet. 2008;23(4):236–242. doi: 10.2133/dmpk.23.236

Figure 1.

Figure 1

Figure 1

Top panel: cerebrospinal fluid (CSF)-to-plasma concentration ratios in Pept2 null mice were 4.0, 6.2 and 8.0 times that of values in wild-type mice for glycylsarcosine (GlySar), cefadroxil and 5-aminolevulinic acid (5-ALA), respectively. Bottom panel: choroid plexus-to-CSF concentration ratios in Pept2 null mice were 0.2, 0.08 and 0.09 times that of values in wild-type mice for GlySar, cefadroxil and 5-ALA, respectively. Samples were obtained 60 min after dosing GlySar (50 nmol/g body weight)23), 120 min after dosing cefadroxil (1 nmol/g body weight)24), and 60 min after dosing 5-ALA (10 nmol/g body weight).27) Data are expressed as mean ± SE (n=6–9).