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. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: Curr Treat Options Neurol. 2008 Nov;10(6):410–419. doi: 10.1007/s11940-008-0043-8

Table 2.

Potential mediators of the effect of the ketogenic diet in neurologic disorders

Direct
 Ketone bodies
  Substrate delivery
  Enhancement of mitochondrial function
   Adenosine triphosphate production
   Decreased effects from reactive oxygen species
 Fatty acids
 Calorie restriction
Indirect
 Neurotransmission
  Neurotransmitters
  Neuropeptides
  Ion channels
 Mitochondrial biogenesis