Table IV.
Permeability Coefficient of HEM, Lag Time, and Transport Enhancement Factor Across HEM Induced by Fatty Acid Deposition from Ethanol Solution
| HEM treatment | Permeability coefficient of HEM for CS with enhancer/ethanol formulation (10−7cm/s)a | Lag time (min)a | Enhancement factorb |
|---|---|---|---|
| Control/Ethanol | 4±2 | 56±4 | NA |
| DCA | 6±2 | NAc | 1.5±0.3 |
| UDA | 10±3 | NAc | 2±2 |
| LRA | 7±4 | 31±12 | 2.6±0.9 |
| TDA | 6±3 | 36±16 | 1.4±0.6 |
| MA | 6.3±0.5 | 46±15 | 3.7±0.7 |
| PDA | 5±1 | 29±19 | 1.2±0.6 |
| PA | 7±3 | 43±17 | 4±2 |
| STA | 3±1 | 53±5 | 1.7±0.6 |
| OL | 14±10 | 49±1 | 5±1 |
| LA | 13±7 | 44±3 | 9±5 |
| RCA | 10±2 | 23±7 | 2.7±0.9 |
a
Mean±SD (n ≥ 3) with at least three different skin donors
b
Enhancement factor determined with HEM after fatty acid/ethanol treatment (ethanol is the volatile carrier)
c
The lag time is not reported due to the large variability attributed to enhancer depletion in the transport experiment