Figure 5. PD-L1 expression on nonhematopoietic cells influences survival and immunopathology after infection.

(A) Chimeric mice were infected with LCMV CL-13 and survival monitored daily. n = 7–10 mice; 1 representative experiment of 3 is shown. (B) Severe pathology in the BM compartment in chimeric mice lacking PD-L1 on nonhematopoietic cells. Representative photomicrographs of BM from CL-13–infected chimeric mice 8 days after infection. Pdl1^–/– mice reconstituted with WT or Pdl1^–/– BM (P-P or W-P) demonstrated significant necrosis of the BM compartment in contrast with W-W and P-W groups, which did not show necrosis. Original magnification, ×400.