Figure 4.

Individual changes in MPAP and PaO₂/FiO₂ induced by increasing inspiratory intratracheal concentrations of inhaled NO (Insp IT NO) in eight patients with ARDS and without septic shock. Mean pulmonary artery pressure was measured: (1) before NO administration (C₁); (2) following seven randomized concentrations of NO between 0.15 and 150 ppm, and (3) after the cessation of NO (C₂). Changes are expressed as percentage variation from C₁ (Δ MPAP and Δ PaO₂/FiO₂) and each patient is represented by a different symbol with a number corresponding to the numbers shown in Tables 1 and 2. In (a) and (b) patients without plateau effect on the dose–response curve are represented. In (c) and (d) patients with a plateau effect on the MPAP dose–response curve and showing a deterioration of their PaO₂/FiO₂ at the highest NO concentrations are represented.