Table 6.
Hemodynamic effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and with septic shock
| NO (ppm) | ||||||||||
| Control 1 | 0.15 | 0.45 | 1.5 | 4.5 | 15 | 45 | 150 | Control 2 | P value* | |
| SPAP (mmHg) | 48± 5 | 43± 5 | 42± 4 | 40± 4 | 39± 3 | 38± 3 | 36± 3 | 36± 3 | 48± 4 | 0.0001 |
| DPAP (mmHg) | 23± 2 | 19± 2 | 20± 2 | 19± 2 | 18± 2 | 18± 2 | 17± 2 | 17± 2 | 22± 2 | 0.0001 |
| MPAP (mmHg) | 32± 3 | 28± 3 | 28± 3 | 27± 3 | 26± 3 | 26± 2 | 24± 2 | 24± 2 | 31± 3 | 0.0001 |
| PVRI (dyn s/cm5m2) | 513± 60 | 395± 39 | 399± 37 | 383± 45 | 352± 35 | 355± 27 | 351± 25 | 362± 33 | 484± 50 | 0.0001 |
| HR (/min) | 91± 8 | 89± 9 | 91± 8 | 95± 8 | 90± 9 | 89± 9 | 89± 7 | 89± 8 | 93± 7 | 0.5331 |
| CI (I/min/m2) | 3.3± 0.3 | 3.3± 0.3 | 3.2± 0.3 | 3.5± 0.3 | 3.3± 0.3 | 3.2± 0.3 | 3.2± 0.3 | 3.1± 0.3 | 3.2± 0.3 | 0.2356 |
| RVSWI (g/m2 | 11± 2 | 10± 2 | 10± 2 | 9± 2 | 9± 2 | 8± 1 | 8± 1 | 7± 1 | 10± 2 | 0.0003 |
| RAP (mmHg) | 10± 2 | 10± 2 | 10± 2 | 9± 2 | 10± 2 | 10± 2 | 9± 2 | 9± 1 | 10± 2 | 0.2142 |
| PCWP (mmHg) | 11± 2 | 11± 1 | 12± 2 | 11± 2 | 11± 2 | 12± 2 | 11± 2 | 10± 2 | 11± 2 | 0.4322 |
| MAP (mmHg) | 74± 5 | 75± 3 | 78± 5 | 77± 3 | 79± 4 | 74± 3 | 73± 4 | 73± 4 | 75± 4 | 0.3197 |
| SVRI (dyn s/cm5m2) | 1709± 236 | 1685± 187 | 1767± 177 | 1695± 184 | 1827± 258 | 1705± 170 | 1731± 219 | 1788± 279 | 1698± 163 | 0.8766 |
NO = nitric oxide; SPAP = systolic pulmonary arterial pressure; DPAP = diastolic pulmonary arterial pressure; MPAP = mean pulmonary arterial pressure; PVRI = pulmonary vascular resistance index; HR = heart rate; CI = cardiac index; RVSWI = right ventricular stroke work index; RAP = right aterial pressure; PCWP = pulmonary capillary wedge pressure; MAP = mean arterial pressure; SVRI = systemic vascular resistance index. Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).