Table 7.
Respiratory effects of increasing inspiratory concentrations of inhaled NO in eight patients with ARDS and with septic shock
| NO (ppm) | ||||||||||
| Control 1 | 0.15 | 0.45 | 1.5 | 4.5 | 15 | 45 | 150 | Control 2 | P value* | |
| PaO2/FiO2 (mmHg) | 128± 18 | 199± 20 | 229± 25 | 232± 28 | 255± 23 | 270± 18 | 283± 24 | 313± 23 | 148± 21 | 0.0001 |
| QVA/QT (%) | 37± 2 | 32± 2 | 30± 1 | 29± 1 | 29± 1 | 27± 1 | 29± 1 | 29± 3 | 35± 1 | 0.0001 |
| SVO2 (%) | 67± 4 | 72± 2 | 73± 2 | 73± 3 | 74± 3 | 74± 3 | 74± 2 | 73± 3 | 69± 3 | 0.0012 |
| DO2 (ml/min/m2) | 416± 38 | 425± 31 | 437± 40 | 455± 41 | 430± 25 | 420± 29 | 417± 35 | 407± 35 | 413± 31 | 0.315 |
| VO2 (ml/min/m2) | 126± 13 | 113± 10 | 114± 9 | 124± 16 | 110± 11 | 114± 12 | 109± 9 | 118± 18 | 121± 11 | 0.2372 |
| PaCO2 (mmHg) | 44± 3 | 43± 3 | 42± 2 | 41± 3 | 41± 2 | 41± 3 | 41± 2 | 42± 3 | 43± 2 | 0.0114 |
| PETCO2 (mmHg) | 30± 2 | 31± 2 | 31± 2 | 30± 2 | 30± 2 | 31± 2 | 30± 2 | 32± 3 | 30± 2 | 0.0829 |
| VDA/VT (%) | 30± 4 | 25± 3 | 25± 3 | 24± 4 | 24± 4 | 24± 4 | 25± 4 | 23± 5 | 28± 4 | 0.0008 |
QVA/QT = venous admixture; SVO2 = mixed venous oxygen saturation; VO2 = oxygen consumption; DO2 = oxygen delivery; PETCO2 = end tidal CO2; VDA/VT = alveolar dead space Values are given as mean ± SEM. *P value for the one-way analysis of variance (dose-response curve).