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. 2010 Jun 23;120(7):2627–2634. doi: 10.1172/JCI42304

Figure 4. Kinetics and distribution of enhancement.

Figure 4

(A and B) T1-weighted short axis MRI of allo- and isografts 7 days after transplantation before and up to 120 minutes after injection of MPO-Gd. Circles indicate location of heart grafts. Data are shown as mean ± SEM; n = 6 per group. (C) Magnified MR image of isograft 120 minutes after injection of MPO-Gd. Some focal bright signal reflects spin refreshment effects due to blood flow. Scale bars: 1 mm. (D) Allograft 120 minutes after injection of MPO-Gd. (E) Same data as in D, but the MPO-Gd signal was thresholded and pseudocolored in red. (F) Immunoreactive staining for MPO in the area that enhances in D and E. Scale bar: 20 μm. (G) Thresholded data of signal enhancement 120 minutes after injection of MPO-Gd show typical enhancement patterns. To highlight the more comprehensive sampling of imaging over the clinical standard, areas that would be accessible to heart biopsies, which are routinely taken from the right ventricular cavity, are color-coded in yellow. Red encodes foci of rejection that could not be reached with routine transvenous right ventricular biopsies.