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. 2010 Jun 23;120(7):2627–2634. doi: 10.1172/JCI42304

Figure 7. Translational potential of MPO as an imaging target for organ rejection.

Figure 7

(A) MPO protein levels measured by flow cytometry in human blood monocyte subsets. (B) MPO in biopsy samples from patients after heart transplantation. H&E stain and immunoreactive staining for MPO in representative sections from patient biopsies. Patient on left had no signs of rejection (grade 0) and no MPO+ cells, whereas patient on the right was graded 3R (severe rejection/high grade infiltrate) and showed MPO+ cells on immunoreactive staining. Scale bar: 20 μm. (C) Quantification of MPO+ cells in patients with no (ISHLT grade 0), mild (1R), and high grade (2/3R) cellular infiltration. Data are shown as mean ± SEM.