Table 1:

The Mean Squared Error (MSE), Relative Efficiency, and Coverage Probability of Nominal 95% Confidence Intervals (CI’s) for the Targeted Maximum Likelihood Estimator (TMLE) vs. Unadjusted Estimator (UNADJ), at Sample Sizes n=100, 500, and 1000.

Data Generating Distribution 1
		MSE	Relative Efficiency	CI Coverage
For n=100:	UNADJ	0.057	1.35	0.93
	TMLE	0.042		0.94
For n=500:	UNADJ	0.012	1.41	0.94
	TMLE	0.008		0.94
For n=1000:	UNADJ	0.006	1.42	0.94
	TMLE	0.004		0.94
Data Generating Distribution 2
		MSE	Relative Efficiency	CI Coverage
For n=100:	UNADJ	0.045	1.10	0.93
	TMLE	0.041		0.92
For n=500:	UNADJ	0.009	1.02	0.95
	TMLE	0.009		0.95
For n=1000:	UNADJ	0.004	1.02	0.95
	TMLE	0.004		0.95
Data Generating Distribution 3
		MSE	Relative Efficiency	CI Coverage
For n=100:	UNADJ	0.031	1.29	0.94
	TMLE	0.024		0.94
For n=500:	UNADJ	0.006	1.31	0.94
	TMLE	0.005		0.95
For n=1000:	UNADJ	0.003	1.31	0.95
	TMLE	0.002		0.95