Table 1.
Summary of studies using BNP or NTproBNP for ris stratification of AMI
| Study Pop | N | Endpoints | Thresholds | Odds ratio or Hazard Ratio | Ref |
|---|---|---|---|---|---|
| ACS-TIMI16 | 2,525 | Death (30 day, 10 months) HF(10 months) MI (10 months) | Quartiles BNP > 80 pg/ml | 1, 3.8, 4.0, 5.8 Approximately 2.7 Approximately 2 | [28] |
| AMI | 70 | Death (18 months) | Median (>59 pg/ml) | Approximately 2.5 | [29] |
| AMI-CONSENSUS | 131 | Death (one year) | 75th centile BNP 33.3 pmol/L | Approximately 1.36 | [30] |
| ACS | 609 | Death | Median | 2.4 | [37] |
| NSTEACS | 1,483 | Death (in hosp) (180 days) | BNP > 586 pg/ml | (1.7) (1.67) | [38] |
| FRISC-II | 2,019 | Death | Top Tertile | 4.1(invasive) vs 3.5(non-invasive) | [36] |
| TACTICS-TIMI18 | 1,676 | Death (six months) HF (30 days) | BNP > 80 pg/ml | OR 3.3 OR 3.9 | [35] |
| ACS | 1,033 | Death (30 day) (six months) | Quartiles | (2.24) (1.84) | [34] |
| AMI | 473 | Death | Median | OR 3.82 | [39] |