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The gene interaction networks of early HCC potential biomarker genes that are conserved in rat early HCCs and in multiple independent human early HCCs. The network analysis of 35 early HCC signature genes indicated the activation of ERK/MAPK, PI3K/AKT and TGF-β signaling pathways, as well as potential critical regulatory roles of MYC, ERbB-2, HNF4A, and SMAD3 for early HCC; top two scoring networks are shown (A, B).
