Table 1.
Functional comparison of hepatoma and regeneration in young and old
| Molecular and Cellular Functions | Significance | Number of genes1 | (%) |
|---|---|---|---|
| Hepatoma in Young | |||
| Cancer | 2.1 × 10-3 - 4.9 × 10-2 | 12 | 33.3 |
| Cellular Development | 4.6 × 10-3 - 4.9 × 10-2 | 8 | 22.2 |
| Immune Response | 2.5 × 10-5 - 4.5 × 10-2 | 7 | 19.4 |
| Skeletal and Muscular System Development and Function | 9.1 × 10-4 - 4.5 × 10-2 | 7 | 19.4 |
| Cell Morphology | 4.6 × 10-3 - 4.9 × 10-2 | 7 | 19.4 |
| Nervous System Development and Function | 4.6 × 10-3 - 4.9 × 10-2 | 6 | 16.7 |
| Hair and Skin Development and Function | 2.1 × 10-5 - 1.4 × 10-2 | 4 | 11.1 |
| Cell Cycle | 8.6 × 10-5 - 4.8 × 10-2 | 4 | 11.1 |
| Cellular Function and Maintenance | 2.1 × 10-4 - 4.5 × 10-2 | 4 | 11.1 |
| Amino Acid Metabolism | 4.6 × 10-3 - 4.9 × 10-2 | 3 | 8.3 |
| Cell Death | 4.6 × 10-3 - 4.9 × 10-2 | 3 | 8.3 |
| Hepatoma in Old | |||
| Cancer | 3.6 × 10-3 - 4.8 × 10-2 | 15 | 46.9 |
| Cellular Movement | 2.3 × 10-3 - 4.8 × 10-2 | 13 | 40.6 |
| Cell-to-Cell Signaling and Interaction | 4.9 × 10-3 - 4.8 10-2 | 10 | 31.3 |
| Tissue Development | 4.7 × 10-3 - 3.9 × 10-2 | 9 | 28.1 |
| Cell Morphology | 4.9 × 10-3 - 4.9 × 10-2 | 9 | 28.1 |
| Organ Development | 3.1 × 10-3 - 4.8 × 10-2 | 6 | 18.8 |
| Embryonic Development | 3.4 × 10-3 - 4.7 × 10-2 | 5 | 15.6 |
| Organ Morphology | 3.1 × 10-3 - 3.4 × 10-2 | 4 | 12.5 |
| Cell Death | 4.9 × 10-3 - 3.9 × 10-2 | 4 | 12.5 |
| Skeletal and Muscular System Development and Function | 4.7 × 10-3 - 1.9 × 10-2 | 3 | 9.4 |
| Amino Acid Metabolism | 4.9 × 10-3 - 4.3 × 10-2 | 2 | 6.3 |
| Regenerated in Young | |||
| Cellular Growth and Proliferation | 1.6 × 10-3 - 4.8 × 10-2 | 5 | 38.5 |
| Skeletal and Muscular System Development and Function | 1.6 × 10-3 - 3.7 × 10-2 | 5 | 38.5 |
| Cell Morphology | 1.6 × 10-3 - 4.9 × 10-2 | 4 | 30.8 |
| Cellular Assembly and Organization | 1.6 × 10-3 - 4.9 × 10-2 | 4 | 30.8 |
| Cell-to-Cell Signaling and Interaction | 1.6 × 10-3 - 4.9 × 10-2 | 4 | 30.8 |
| Small Molecule Biochemistry | 1.6 × 10-3 - 4.7 × 10-2 | 4 | 30.8 |
| Tissue Development | 1.9 × 10-3 - 4.8 × 10-2 | 4 | 30.8 |
| Cellular Development | 1.6 × 10-3 - 4.9 × 10-2 | 3 | 23.1 |
| Cell cycle | 1.4 × 10-3 - 5.0 × 10-2 | 3 | 23.1 |
| Amino Acid Metabolism | 1.6 × 10-3 - 4.6 × 10-2 | 2 | 15.4 |
| Cellular Function and Maintenance | 1.6 × 10-3 - 3.2 × 10-2 | 2 | 15.4 |
| Nervous System Development and Function | 1.6 × 10-3 - 4.8 × 10-2 | 2 | 15.4 |
| Regenerated in Old | |||
| Nervous System Development and Function | 4.2 × 10-5 - 4.2 × 10-2 | 22 | 37.9 |
| Molecular Transport | 3.8 × 10-3 - 4.2 × 10-2 | 19 | 32.8 |
| Cell Morphology | 1.3 × 10-4 - 3.8 × 10-2 | 15 | 25.9 |
| Small Molecule Biochemistry | 1.1 × 10-3 - 4.2 × 10-2 | 15 | 25.9 |
| Cellular Movement | 1.5 × 10-3 - 4.2 × 10-2 | 15 | 25.9 |
| Cell Signaling | 7.1 × 10-3 - 2.3 × 10-2 | 15 | 25.9 |
| Cell-to-Cell Signaling and Interaction | 7.1 × 10-3 - 3.9 × 10-2 | 12 | 20.7 |
| Tissue Morphology | 2.3 × 10-4 - 4.2 × 10-2 | 11 | 19.0 |
| Lipid Metabolism | 1.1 × 10-3 - 3.8 × 10-2 | 10 | 17.2 |
| Cellular Growth and Proliferation | 3.2 × 10-3 - 3.7 × 10-2 | 10 | 17.2 |
| Skeletal and Muscular System Development and Function | 3.2 × 10-3 - 3.7 × 10-2 | 9 | 15.5 |
| Cellular Assembly and Organization | 7.1 × 10-3 - 4.1 × 10-2 | 8 | 13.8 |
| Cellular Function and Maintenance | 7.1 × 10-3 - 3.5 × 10-2 | 7 | 12.1 |
| Cellular Development | 1.9 × 10-4 - 3.7 × 10-2 | 5 | 8.6 |
1Thirty six, 32, 13, and 94 genes of the signature genes for HCC in young, HCC in old, Regenerated in young and Regenerated in old, respectively, mapped to corresponding genes in the knowledgebase.