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Inhibition of HIV-1 replication
| shRNAs | |||||
|---|---|---|---|---|---|
| Target | wt | G8A | G15A | wt+G8A | wt+G8A+G15A |
| wt | ++a (0)b | - (1) | - (1) | ++ (0.1)c | ++ (0.1.1)c |
| G8A | - (1) | ++ (0) | - (1) | ++ (1.0) | ++ (1.0.1) |
| G15A | - (1) | - (1) | ++ (0) | - (0.1) | ++ (1.1.0) |
| +G8A+G15A | - (2) | - (1) | ++ (1) | - (2.1) | - (2.1.1) |
a score of RNAi activity
b number of mismatches
c number of mismatches per shRNA
