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Changes in arterial pH, PaO2, HCO3-, and base excess in anesthetized dogs after 2 h intravenous administration of (a) isotonic saline or (b) bacterial lipopolysaccharide (LPS: 250 ng/kg/min) with or without 1 h infusion or carboxy-PTIO (0.1 mg/kg/min). Each point represents the mean of sham-vehicle group (n = 3), sham-carboxy-PTIO group (n = 3), LPS group (n = 7), and LPS plus carboxy-PTIO group (n = 7); bar shows SEM. *P < 0.05, **P < 0.01 vs baseline value.
