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. 1997 Sep 26;1(1):45–50. doi: 10.1186/cc6

Table 2.

Hemodynamic and gas exchange parameters in anesthetized dogs after intravenous administration of bacterial lipopolysaccharide with or without carboxy-PTIO

Hours

Parameters Treatment 0 0.5 1 2 3 4
HR (beats/min) LPS 143 ± 18 144 ± 8 150 ± 11 152 ± 6 157 ± 8 155 ± 10
Carboxy-PTIO 144 ± 13 147 ± 12 154 ± 12 156 ± 11 155 ± 11 158 ± 12
MPAP (mmHg) LPS 17 ± 13 17 ± 13 16 ± 13 18 ± 4 18 ± 4 19 ± 5
Carboxy-PTIO 16 ± 1 16 ± 1 16 ± 1 17 ± 1 17 ± 1 17 ± 1
PCWP (mmHg) LPS 8 ± 2 7 ± 1 7 ± 2 7 ± 2 7 ± 2 8 ± 2
Carboxy-PTIO 8 ± 1 8 ± 1 8 ± 1 8 ± 1 9 ± 1 9 ± 1
CVP (mmHg) LPS 4 ± 1 4 ± 1 3 ± 1 3 ± 1 4 ± 1 5 ± 1
Carboxy-PTIO 4 ± 1 3 ± 1 4 ± 1 4 ± 1 5 ± 1 4 ± 1
PVRI (dyn s/cm5m2) LPS 180 ± 22 - 201 ± 17 270 ± 34 229 ± 35 252 ± 51
Carboxy-PTIO 157 ± 13 - 168 ± 11 177 ± 17 208 ± 17 229 ± 27
DO2I (ml min/m2) LPS 592 ± 59 - 538 ± 49 438 ± 43 482 ± 44 439 ± 35
Carboxy-PTIO 722 ± 83 - 725 ± 65 679 ± 64 616 ± 58 558 ± 50
VO2I (ml min/m2) LPS 128 ± 17 - 115 ± 12 117 ± 14 127 ± 18 124 ± 12
Carboxy-PTIO 125 ± 12 - 123 ± 12 120 ± 13 123 ± 16 130 ± 17

Values are mean ± SEM (n = 7). LPS = lipopolysaccharide; HR = heart rate; MPAP = mean pulmonary arterial pressure; PCWP = pulmonary capillary wedge pressure; CVP = central venous pressure; PVRI = pulmonary vascular resistance index; DO2I = O2 delivery index; VO2I = O2 consumption index;- = not measured.