Table 2.
Hemodynamic and gas exchange parameters in anesthetized dogs after intravenous administration of bacterial lipopolysaccharide with or without carboxy-PTIO
| Hours | |||||||
| Parameters | Treatment | 0 | 0.5 | 1 | 2 | 3 | 4 |
| HR (beats/min) | LPS | 143 ± 18 | 144 ± 8 | 150 ± 11 | 152 ± 6 | 157 ± 8 | 155 ± 10 |
| Carboxy-PTIO | 144 ± 13 | 147 ± 12 | 154 ± 12 | 156 ± 11 | 155 ± 11 | 158 ± 12 | |
| MPAP (mmHg) | LPS | 17 ± 13 | 17 ± 13 | 16 ± 13 | 18 ± 4 | 18 ± 4 | 19 ± 5 |
| Carboxy-PTIO | 16 ± 1 | 16 ± 1 | 16 ± 1 | 17 ± 1 | 17 ± 1 | 17 ± 1 | |
| PCWP (mmHg) | LPS | 8 ± 2 | 7 ± 1 | 7 ± 2 | 7 ± 2 | 7 ± 2 | 8 ± 2 |
| Carboxy-PTIO | 8 ± 1 | 8 ± 1 | 8 ± 1 | 8 ± 1 | 9 ± 1 | 9 ± 1 | |
| CVP (mmHg) | LPS | 4 ± 1 | 4 ± 1 | 3 ± 1 | 3 ± 1 | 4 ± 1 | 5 ± 1 |
| Carboxy-PTIO | 4 ± 1 | 3 ± 1 | 4 ± 1 | 4 ± 1 | 5 ± 1 | 4 ± 1 | |
| PVRI (dyn s/cm5m2) | LPS | 180 ± 22 | - | 201 ± 17 | 270 ± 34 | 229 ± 35 | 252 ± 51 |
| Carboxy-PTIO | 157 ± 13 | - | 168 ± 11 | 177 ± 17 | 208 ± 17 | 229 ± 27 | |
| DO2I (ml min/m2) | LPS | 592 ± 59 | - | 538 ± 49 | 438 ± 43 | 482 ± 44 | 439 ± 35 |
| Carboxy-PTIO | 722 ± 83 | - | 725 ± 65 | 679 ± 64 | 616 ± 58 | 558 ± 50 | |
| VO2I (ml min/m2) | LPS | 128 ± 17 | - | 115 ± 12 | 117 ± 14 | 127 ± 18 | 124 ± 12 |
| Carboxy-PTIO | 125 ± 12 | - | 123 ± 12 | 120 ± 13 | 123 ± 16 | 130 ± 17 | |
Values are mean ± SEM (n = 7). LPS = lipopolysaccharide; HR = heart rate; MPAP = mean pulmonary arterial pressure; PCWP = pulmonary capillary wedge pressure; CVP = central venous pressure; PVRI = pulmonary vascular resistance index; DO2I = O2 delivery index; VO2I = O2 consumption index;- = not measured.