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. 2010 Jul 7;5(7):e11414. doi: 10.1371/journal.pone.0011414

Table 3. Adverse events reported with IV vitamin C use in the survey for the years 2006 and 2008.

Number of Patients
Complication 2006 2008
None Described 5349 3878
Lethargy/Fatigue 10 49
Local Vein Irritation 3 -
Phlebitis 3 -
Kidney Stone (oxalate) - 1
Kidney Stone (urate) - 1
Kidney Stone (unspecified) 2 -
Hemolysis 2 -
Elevated Blood Glucose 2 -
Muscle Cramps 1 -
Headache 1 -
Change in Mental Status 1 20
Nausea/Vomiting 1 -
Flu Like Syndrome 1 -
Renal Failure - 1*
Syncope - 1
Pain at Tumor - 1
No Data 5857 4924

Data included in the table represent only those practitioners who reported exact patient numbers.

*Described as “not confirmed (possible). Patient had partial renal failure and cancer metastases to kidneys.”

Data on practitioners who reported adverse events but did not report the number of patients affected are detailed below as: side effect (with the number of practitioners who reported each side effect in parenthesis).

For the year 2006: lethargy/fatigue (9), local vein irritation (3), nausea/vomiting (2), hypoglycemia (2), allergy (2), phlebitis (1), cellulitis (1), hematuria (1), dry mouth (1), Herxheimer reaction (1), localized thrombosis (1), and syncope (1).

For the year 2008: lethargy/fatigue (9), nausea/vomiting (6), local vein irritation (4), headache (3), phlebitis (3), heartburn (1), dizziness (1), venosclerosis (1), mild palpitation (1), and cold (1), dizziness (1), “initiation of mem occasionally” (1), and other (1).