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. 2010 Jun 16;30(24):8203–8213. doi: 10.1523/JNEUROSCI.1216-10.2010

Figure 2.

Figure 2.

Activation of amygdala mGluR5 induces mechanical hypersensitivity. A, B, DHPG, a selective group I mGluR agonist, injected into the right amygdala (0.01 nmol, n = 8; 0.1 nmol, n = 8) causes significant mechanical hypersensitivity 30 min after injection in both the left (A) and right (B) paws compared with vehicle-treated mice (n = 8). C, D, DHPG injected into the left amygdala (n = 11) causes mechanical hypersensitivity in the right (D) but not in the left (C) paw compared with vehicle-treated mice (n = 10). Gray areas in brain illustrations are representative of WT mGluR5 expression. Data are expressed as mean ± SEM. Repeated-measures ANOVA with Bonferroni post-test: **p < 0.01, ***p < 0.001, compared with vehicle-treated group at specified time point; ##p < 0.01, ###p < 0.001, compared with baseline for specified group.