Table VI.
Results of haplotype transmission analysis according to cleft subgroup by population.
Marker Haplotype | Genes in Haplotype | Cleft Group | Population | HBAT P-value2 |
---|---|---|---|---|
rs357654-rs2236407 | PTCH-PTCH | CLO + CLCLP1 | Guatemala | 0.01 |
rs10512248-rs894673 | PTCH-FOXE1 | CLO + CLCLP | Guatemala | 0.01 |
rs2297088-rs10512248-rs894673 | PTCH-PTCH-FOXE1 | CLO + CLCLP | Guatemala | 0.01 |
rs2236407-rs2297088-rs10512248-rs894673 | PTCH-PTCH-PTCH-FOXE1 | CLO + CLCLP | Guatemala | 0.01 |
rs10512248-rs894673 | PTCH-FOXE1 | CLO + CLCLP | China | 0.03 |
rs10512248-rs894673-rs3758249 | PTCH-FOXE1-FOXE1 | CLO + CLCLP | China | 0.03 |
rs10512248-rs894673-rs3758249-rs10984103 | PTCH-FOXE1-FOXE1-C9orf156 | CLO + CLCLP | China | 0.03 |
CLO + CLCLP, families where all affecteds have cleft lip only plus families where at least one affected has cleft lip only and one affected has cleft lip and palate. Excludes any family where an affected has cleft palate only.
Transmission distortion significant when p<0.05.