Table II.

Confirmed or putative virulence factors of A. pleuropneumoniae involved in acquisition of essential nutrients and their corresponding genes.

(Putative) function	Gene	Reference
Iron acquisition TonB1 cluster	tonB1-exbB1-exbD1-tpbB-tbpA	[5, 6, 8, 37, 40, 54–56, 88, 96, 112, 121]
Iron acquisition TonB2 cluster	exbB2-exbD2-tonB2	[12, 40]
Ferric hydroxamate uptake	fhuA, fhuB, fhuC, fhuD	[41, 70, 78, 79, 103]
Hemoglobin-binding protein A precursor	hgbA	[4, 5, 15, 40, 103, 107]
Putative nickel and cobalt periplasmic permease system	cbiKLMQO	[5, 22]
Maltose regulon	malEFG, malK-lamB-malM, malT, malPQ	[39, 75, 76]
Double stranded DNA binding	comE1	[80]
ferric transporter	afuB, afuC	[70, 75]
Putative arginine/ornithine antiporter	arcD	[70]
Arginine transport system permease protein	artQ	[40]
Branched-chain amino acid transport system carrier protein	brnQ	[75, 76]
Putative ferric enterobactin transporter binding protein	fetB2	[40]
Iron-regulated outer membrane protein B	frpB	[75, 76]
Glycerol uptake facilitator and transporter	glpF, glpT	[5, 40, 70, 75, 76]
D-ribose binding periplasmic and transport protein	rbsB, rbsD	[40, 75, 76]
Peptide transport system permease protein	sapC	[40]
Serine transporter	sdaC	[75, 76]
Thiamine transport ATP-binding protein	thiQ	[70]
Colicin transport proteins	tolQ, tolR	[5, 76]
Urea transport	utp	[22]
Iron (chelated) ABC transporter, periplasmic binding protein	yfeA, yfeB, yfeC, yfeD	[5, 40, 75], [105]