Table 1.
Iliac crest, lumbar spine and femoral cancellous bone structural histomorphometry (mean ± SEM) at different time points for the control and the treated sheep
| Baseline | Control | Treated | ||
|---|---|---|---|---|
| 0 month (n = 2) | 6 month (n = 2) | 3 month (n = 5) | 6 month (n = 5) | |
| Iliac crest | ||||
| BV/TV (%) | 18.1 ± 0.7 | 17.9 ± 1.6 | 15.4 ± 0.9 | 13.1 ± 1.2‡,* |
| Tb.Th (mm) | 0.11 ± 0.0 | 0.12 ± 0.0 | 0.09 ± 0.0 | 0.08 ± 0.0‡,* |
| Tb.Sp (mm) | 0.50 ± 0.03 | 0.57 ± 0.1 | 0.49 ± 0.02 | 0.57 ± 0.02 |
| Tb.N (#/mm) | 1.60 ± 0.07 | 1.50 ± 0.2 | 1.72 ± 0.06 | 1.60 ± 0.2 |
| Lumbar spine | ||||
| BV/TV (%) | 28.1 ± 1.7 | 33.9 ± 1.9 | 21.9 ± 0.7 | 19.9 ± 0.7‡,* |
| Tb.Th (mm) | 0.15 ± 0.0 | 0.16 ± 4.6 | 0.11 ± 0.00 | 0.10 ± 0.00‡,* |
| Tb.Sp (mm) | 0.5 ± 0.03 | 0.32 ± 0.03 | 0.41 ± 0.02 | 0.41 ± 0.02 |
| Tb.N (#/mm) | 1.6 ± 0.07 | 2.13 ± 0.2 | 1.97 ± 0.07 | 2.03 ± 0.1 |
| Proximal femur | ||||
| BV/TV (%) | 26.5 ± 4.8 | 31.7 ± 2.1 | 14.7 ± 0.8 | 15.2 ± 1.7†,** |
| Tb.Th (mm) | 0.17 ± 0.05 | 0.15 ± 0.0 | 0.12 ± 0.01 | 0.12 ± 0.00 |
| Tb.Sp (mm) | 0.47 ± 0.02 | 0.33 ± 0.02 | 0.70 ± 0.05 | 0.71 ± 0.08‡,* |
| Tb.N (#/mm) | 1.57 ± 0.2 | 2.08 ± 0.04 | 1.23 ± 0.07 | 1.25 ± 0.1†,** |
Testing the significant differences of the histomorphometry data from the 6-month treated with the baseline († P < 0.05, ‡ P < 0.01) and 6-month control sheep (* P < 0.05, ** P < 0.01)