Table 12.

Resection extent: summary of studies reporting influence of resection extent on outcome regardless of histology

Author (reference)	Quality	Year	Patients	EOR	Patients	Outcome studied	Result	Comment
Reimer [58] (p)	B	1985	32	GTR	2	7-year OS (%)
				STR	22		100 (↑)	p = 0.02
				Bio	8		42.7 (↓)
Hardison [22] (p)	B	1987	25	STR/PR	8	18-month PFS (%)	38	p NR
				Bio	17		41
Sandler [64]	A	1992	21	GTR	3	Recurrence (%)	0	p NR
				STR	7		43
				Bio	11		36
Huddart [24]	A	1993	27	PR/STR	10	5-year OS (%)	73	p NS
				Bio	17		53
Hulshof [25]	B	1993	13	PR	5	Recurrence (%)	0	p NR
				Bio	8		75
Minehan [49]	A	1995	79	STR/GTR	24	5-year/10-year OS (%)	NR	p = 0.081 in favor of Bio
				Bio	55
Innocenzi [27]	B	1997	65	GTR	10	5-year OS (%)	80	p NR
				STR	Unclear		59
				Bio	Unclear		56
Przybylski [56] (p)	A	1997	18	GTR	5	Recurrence (%)	0 (↑)	FU 5-14 years
				STR/Bio	13		69 (↓)	p = 0.029
Jyothirmayi [30]	A	1997	23	GTR/STR	13	5-year PFS/OS (%)	91/68	PFS p = 0.07
				Bio	10		58/38	OS p = 0.09
Bouffet [5] (p)	A	1998	73	GTR	11	10-year OS (%)	90 (↑)	Univariate p = 0.08
				Other	62		64 (↓)	Multivariate NS
Rodrigues [60]	A	2000	52	GTR	5	5-year PFS/CSS (%)	NR	EOR not significant
				STR	20
				Bio	27
Kim [34]	A	2001	28	GTR/STR	9	Median survival (months)	113	p = 0.468
				PR/Bio	19		102
Lee [41]	A	2003	25	GTR	1	LC/PFS/OS	NR	LC p = 0.64
				STR	5			PFS p = 0.32
				Bio	19			OS p = 0.52
Abdel-Wahab [2]	A	2006	57	GTR	13	15-year PFS; HR reduction	84% GTR	p = 0.01
				Other	40
				Unknown	4	15-year OS	NS	p = 0.25

↑ positive influence on outcome measure, ↓ negative influence on outcome measure