Table 18.

Best scoring seven studies: summary of significant and not significant prognostic factors as well as conclusions for extent of resection and radiotherapy in studies scoring more than 20 points on quality assessment

Author (reference)	Points	Population	Factors not significant	Favorable significant factors	Conclusion EOR	Conclusion RT
Huddart [24]	21.5	Overall	Age, symptom duration, location, extent, bowel/bladder fct., neurological fct., EOR (Bio vs. PR/STR), Rx dose (50 Gy)	LG, female gender, syrinx/cyst presence	Inconclusive	Helps to achieve LC
Constantini [8] (p)	20	Age less than 3 years	Age, LG glioma vs. ganglioglioma	LG	GTR possible with reasonable MM	Not recommended: infant population
Przybylski [56] (p)	20.5	Children	Age, year of diagnosis, degree of anaplasia	GTR	GTR achieves survival free of relapse	Less than GTR—achieves long-term survival at the expense of frequent relapse
Rodrigues [60]	20	Overall	Gender, EOR, RT dose	Younger age, longer history length, LG	Inconclusive	Should be given to delay progression
						After GTR may not be necessary
Constantini [9] (p)	20.5	Children and young adults	NR for astrocytoma	LG	GTR and STR (80%+) equally efficacious for 10-year PFS in LG	Not recommended for LG after radical surgery
Robinson [59]	22.5	LG tumors	Age, gender, syrinx/cyst, extent, symptom duration, KPS, neurological fct., EOR, RT use	Trend Bio vs. more extensive resection	Inconclusive	LG: if GTR, RT not necessary
						Anything less, recommended
McGirt [46] (m)	21	HG tumors	Number of resections, extent, age, CHT use (all for gr. III tumors)	Grade III vs. IV, no tumor dissemination	gr. III: GTR superior to STR	Not stated: HG tumor study