Table 2.
Summary of intramedullary astrocytoma studies
| Author (reference) | Study period | Study type | Patients | Resection assessment | Histology review | GTR (%) | Radiotherapy (%) | HG tumors (%) | Follow-up [median (range)] | Lost to follow-up | Quality (points) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Kopelson [37] | 1962–1980 | Retrospective single center | 14 | NR | Local | 0 (0) | 14 (100) | 5 (36) | NR | 2 | B (12) |
| Reimer [58] (p) | 1955–1980 | Retrospective single center | 32 | NR | NR | 2 (6) | 26 (81) | 5 (16) | NR | 3 | B (13) |
| Cohen [7] (m) | 1981–1987 | Retrospective single center | 19 | Intraop. ultrasonography | NR | NR | 18 (95) | 19 (100) | 9.5 (1–28) months | 0 | A (16.5) |
| Rossitch [61] (p) | Since 1952 | Retrospective single center | 12 | NR | Local | 4 (33) | 6 (50) | 0 (0) | 10.5 (0.5–38) yearsa | 0 | B (9) |
| Sandler [64] | 1975–1989 | Retrospective single center | 21 | Intraop. ultrasonography | NR | 3 (14) | 15 (71) | 2 (9) | NR | 1 | A (15) |
| Epstein [15] | 1982–1990 | Retrospective single center | 25 | Intraop. ultrasonography | NR | 25 (100) | 7 (28) | 6 (24) | 38 (4–82) months | 0 | A (16.5) |
| Huddart [24] | 1966–1989 | Retrospective single center | 27 | Surgery | Local | 0 (0) | 27 (100) | 6 (22) | 6.5 (0.1–13.5) years | 0 | A (21.5) |
| Minehan [49] | 1958–1988 | Retrospective single center | 79 | NR | Local | 4 (5) | 64 (81) | 9 or 12 (11 or 15)b | NR | NR | A (18) |
| Innocenzi [27] | 1953–1990 | Retrospective single center | 65 | NR | Local | 10 (15) | 20 (31) | 10 (15) | 7.3 (0.5–27) yearsa | 7 | B (14) |
| Przybylski [56] (p) | 1976–1992 | Retrospective single center | 18 | Surgery + MRI | Local | 5 (28) | 9 (50) | 7 (39) | 11 (3–18) years | 0 | A (20.5) |
| Jyothirmayi [30] | 1984–1993 | Retrospective single center | 29 | NR | Local | 0 (0) | 29 (100) | 6 (21) | 51 (7–143) months | 0 | A (19) |
| Bouffet [5] (p) | 1971–1994 | Retrospective 13 centers | 73 | Surgery + MRI | Central | 11 (15) | 37 (51) | 24 (33) | 4.2 (0.4–23) years | 3 | A (17.5) |
| Kim [34] | 1978–1999 | Retrospective single center | 30 | Surgery + MRI | Local | 9 (30) | 19 (63) | 10 (33) | 31.9 (0.5–184) monthsa | 2 | A (19.5) |
| Jallo [28] | 1988–1994 | Retrospective single center | 17 | Surgery + MRI | Local | 12 (70) | 9 (53) | 0 (0) | 86.8 (33–158) months | 0 | A (19) |
| Santi [65] (m) | 1962–2000 | Retrospective single center | 36 | NR | Local | 7 (19) | 25 (69) | 36 (100) | 17 (1–84) months | 0 | B (14) |
| Lee [41] | 1970–1999 | Retrospective single center | 25 | NR | Local | 1 (4) | 21 (84) | 10 (40) | 54 (10–313) months | 0 | A (18) |
| Robinson [59] | 1980–2003 | Retrospective single center | 14 | Surgery + imaging | Local | 1 (7) | 10 (71) | 0 (0) | 10.2 (1.3–23.4) yearsa | 0 | A (22.5) |
| Nakamura [51] | 1986–2002 | Retrospective single center | 30 | NR | Local | 7 (23) | 19 (63) | 12 (40) | 5.5 (1–16.5) yearsa | 0 | B (11) |
| McGirt [46] (m) | 1990–2002 | Retrospective single center | 35 | MRI | Local | 12 (34) | 33 (94) | 35 (100) | 52 ± 28 monthsa | 3 | A (21) |
p: series of pediatric patients, m: series of high-grade tumors
aMean follow-up
bTwo different histological classifications applied