Table 3.
Summary of intramedullary spinal cord tumor studies dealing with astrocytoma patients
| Author (reference) | Study period | Study type | Astrocytoma patients (all patients) | % | Resection assessment | Histology review | GTR (%) | Radiotherapy (%) | HG tumors (%) | Follow-up [median (range)] | Lost to follow-up | Quality (points) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kopelson [38] | 1962–1979 | Retrospective single center | 11 (23) | 48 | Surgery | Local | 0 (0) | 9 (82) | 4 (36) | 33.3 (6–105) months | 0 | B (14) |
| Guidetti [20] | 1951–1978 | Retrospective single center | 58 (129) | 45 | Surgery | NR | 2 (3) | 29 (50) | 5 (9) | 1–27 years | 6 | B (9) |
| Garcia [18] | 1954–1979 | Retrospective single center | 15 (37) | 40 | Surgery | NR | 1 (3) | 15 (100) | NR | 11 (4–29) years | 2 | B (12) |
| Hardison [22] (p) | 1970–1984 | Retrospective single center | 23 (26) | 88 | NR | NR | 1 (4) | 16 (69) | 6 (26) | 4.6 (1–14) years | 0 | B (12) |
| Linstadt [42] | 1957–1986 | Retrospective single center | 15 (42) | 36 | Surgery | NR | 0 (0) | 15 (100) | 3 (20) | 11.2 (4.8–28.2) years | 0 | B (10) |
| Cooper [10] | 1981–1987 | Retrospective single center | 18 (52) | 35 | NR | NR | 9 (50) | 18 (100) | 7 (39) | 38 (2–72) monthsa | 1 | A (15) |
| Hulshof [25] | 1970–1990 | Retrospective two centers | 13 (50) | 26 | Surgery | No | 0 (0) | 12 (92) | 3 (23) | 5 (0.25–19) yearsa | 0 | B (13) |
| Cristante [11] | 1984–1992 | Retrospective single center | 23 (86) | 27 | Surgery | NR | 8 (35) | 0 (0) | 6 (26) | 4.5 (0.7–9) yearsa | 1 | B (14) |
| O’Sullivan [54] (p) | 1959–1990 | Retrospective single center | 15 (31) | 50 | Surgery | Local | NR | 15 (100) | 3 (20) | 11 (1.2–26) years | 0 | B (12) |
| Samii [62] | 1977–1992 | Retrospective single center | 37 (100) | 37 | Surgery + MRI | No | 3 (8) | NR | NR | 24 ± 34 months | NR | A (17.5) |
| Shirato [66] | 1979–1993 | Retrospective single center | 13 (36) | 36 | NR | Local | 1 (8) | 13 (100) | 6 (46) | 3.7 (0.2–12.3) years | 0 | A (16) |
| Constantini [8] (p) | 1980–1993 | Retrospective single center | 15 (27) | 56 | Intraop. ultrasonography + MRI | Local, 2 reviewers | 19 (70) | 3 (20) | 3 (20) | 76 (20–143) months | 2 | A (20) |
| Innocenzi [26] (p) | 1955–1992 | Retrospective two centers | 29 (45) | 64 | Surgery | NR | 10 (34) | 2 (7) | 0 (0) | 3–32 years | NR | B (12) |
| McLaughlin [47] | 1969–1991 | Retrospective single center | 12 (22) | 55 | NR | Local | 1 (8) | 12 (100) | 4 (33) | NR | 0 | B (12) |
| Rodrigues [60] | 1960–1997 | Retrospective single center | 48 (52) | 92 | NR | Local | 5 (10) | 48 (100) | 10 (19) | 3.7 (0.2–27) years | NR | A (20) |
| Constantini [9] (p) | 1980–1994 | Retrospective single center | 76 (164) | 46 | Surgery + MRI | Local, 2 reviewers | 126 (77) | 20 (12) | 18 (24) | 85 (20–191) monthsa | 9 | A (20.5) |
| Raco [57] | 1972–2003 | Retrospective single center | 86 (202) | 43 | Part MRI | NR | 27 (31) | NR | 18 (21) | 6.7 (0.4–18) yearsa | 4 | A (19.5) |
| Abdel-Wahab [2] | 1953–2000 | Retrospective six centers | 57 (242) | 24 | NR | Central | 13 (23) | 39 (68) | 10 (17) | 21 (2–164) months | 59 | A (18) |
| Nakamura [52] | 1994–2003 | Retrospective single center | 23 (68) | 34 | NR | Local, 2 reviewers | 7 (30) | NR | 12 (52) | 6.2 (2.5–11.4) yearsa | NR | B (13) |
Numbers in italics apply to all patients within the intramedullary tumor series
p: series of pediatric patients
aMean follow-up