Table 7.
Functional status: summary of studies reporting analysis of functional status as a prognostic factor
| Author (reference) | Quality | Year | Patients | Scale used | Grade | Patients | Outcome studied | Result | Comment |
|---|---|---|---|---|---|---|---|---|---|
| Huddart [24] | A | 1993 | 27 | Cohen [7] | II and III | 17 | 5-year OS (%) | 67 | Not significant |
| IV | 10 | 44 | |||||||
| Jyothirmayi [30] | A | 1997 | 23 | Cohen [7] | II | 11 | 5-year PFS/OS (%) | 90/82 | PFS p = 0.4 |
| III and IV | 12 | 63/33 | OS p = 0.08 | ||||||
| Przybylski [56] (p) | A | 1997 | 18 | McCormick [45] | I and II | 16 | Recurrence | No effect | |
| III and IV | 2 | ||||||||
| Innocenzi [27] | B | 1997 | 65 | Karnofsky [33] | 80–100 | 10 | 5-year OS (%) | 75 (↑) | Significant difference, p NR |
| 60–70 | 24 | 65 | |||||||
| <60 | 31 | 51 (↓) | |||||||
| Kim [34] | A | 2001 | 28 | Cohen [7] | I and II | 13 | Mean/median survival (months) | 149.5/184 (↑) | p < 0.05 |
| III and IV | 15 | 22.5/6 (↓) | |||||||
| Lee [41] | A | 2003 | 25 | McCormick [45] | I and II | NR | 5-year LC/PFS/OS (%) | NS/NS/73 (↑) | LC p = 0.088 |
| III and IV | NS/NS/22 (↓) | PFS p = 0.09 | |||||||
| OS p = 0.04 | |||||||||
| Robinson [59] | A | 2005 | 14 | McCormick [45] Karnofsky [33] |
Not stratified | 5-, 10-, 20-year OS, PFS | No effect | ||
| McGirt [46] (m) | A | 2008 | 35 | Modified McCormick [45] | I and II | 16 | Median survival | No effect | |
| III and IV | 19 |
↑ positive influence on outcome measure, ↓ negative influence on outcome measure, p: series of pediatric patients, m: series of high-grade tumors