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(Scheme 3) 5 reacts with 9 to the tert-butyl ester of the peptide nucleic acid monomer (Fmoc protected) 10 as a reaction product. After hydrolysis of the tert-butyl ester, catalyzed by acid, the peptide nucleic acid monomer (Fmoc protected) was functionalized with the Reppe anhydride 11 referred to as RE-PNA in the text. According the scheme 3 the synthesis consists of two procedures carried out as described in detail in the footnote 2.
