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. 2010 Jul 4;6(4):396–406. doi: 10.7150/ijbs.6.396

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Expression of FUS in spinal motor neurons remains sustainable in mouse lifetime. A, B, Immunohistochemistry showing that large cells in the ventral horn of spinal cord expressed FUS protein at sustainable levels while the population of FUS-expressing cells was markedly decreased in aged mice. Lumbar spinal cords were dissected from C57BL6 mice at varying ages and cut into transverse sections on a Cryostat. Tissue sections were immunostained with an antibody against FUS. Scale bars: A, 100 μm; B, 20 μm. C, Immunofluorescence staining showing that the motor neurons of lumbar spinal cord expressed FUS at sustainable levels in mouse lifetime.