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Effect of TPZ on radiation killing of CAL-33 cells in vitro under normoxic (A) and hypoxic conditions (B). CAL-33 cells or MnSOD-PL transfected CAL-33 cells were either (A) incubated in TPZ 10 μM for 1 hour and irradiation survival curves performed under normal oxygen conditions, or B) held for 18 hours at 3% oxygen prior to TPZ treatment and irradiation.
