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. Author manuscript; available in PMC: 2010 Jul 8.
Published in final edited form as: In Vivo. 2010 Jan–Feb;24(1):1–8.

Figure 6.

Figure 6

Micro-PET scan showing the effect of MnSOD plus 18 Gy on CAL-33 orthotopic tumors in the cheek of athymic nude mice. Ten days after injection of 1×106 CAL-33 cells into each cheek, the mice were injected with MnSOD-PL 100 μg/100 μl (mouse on left) or with blank-PL (mouse on right) then irradiated with 18 Gy to the head and neck. The next day mice received i.v. FMISO (200 uCi) (A) and were scanned. Twnty-four hours later the mice were reimaged after FDG injection (B). Mouse on right in A displays a big hypoxic tumor as identified by the uptake of FMISO (yellow area – arrow); in the corresponding FDG image (B) the tumor shows reduced FDG uptake in the same region suggesting an area of necrosis or hypoxia. Mouse (left) that received MnSOD-PL shows reduced hypoxic area.