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. Author manuscript; available in PMC: 2010 Jul 8.
Published in final edited form as: In Vivo. 2010 Jan–Feb;24(1):1–8.

Figure 8.

Figure 8

Increased radiocontrollability in orthotopic oral cavity CAL-33 squamous cell carcinoma tumor-bearing nu/nu mice by tirapazamine (TPZ), cetuximab (C225), and MnSOD-PL administration. Groups of ten adult nu/nu female mice were injected in the cheek pouch with 1×106 CAL-33 cells. The treatments were administered at 10 days (0.3 cm diameter) and tumor volume monitored. Control: no treatment; MnSOD-PL (100 μl containing 100 μg plasmid) intraorally, TPZ (60 mg/kg) intraperitoneally in 0.1 ml, + C225 100 μl containing 10 mg/kg intraperitoneally; treated mice received either 14 Gy (A) or 18 Gy (B) to the oral cavity.