TABLE 4.
Type of cancer, prior chemotherapy and best response to current chemotherapy
| Disease Site | Prior fluoropyrimidine? | Number of prior chemotherapy regimens | Best response |
|---|---|---|---|
| Dose Level 1 | |||
| Colorectal | yes | 2 | PD |
| Colorectal | yes | 4 | SD |
| Esophageal | yes | 1 | SD |
| Dose Level 2 | |||
| Cholangiocarcinoma | yes | 3 | N/A |
| Colorectal | yes | 1 | PD |
| Colorectal | yes | 3 | N/A |
| Unknown | no | 0 | SD |
| Pancreas | no | 1 | SD |
| Gastric | no | 0 | PR |
| Esophageal | no | 1 | PR |
| Pancreatic | no | 1 | PD |
| Cholangiocarcinoma | no | 0 | PD |
| Cholangiocarcinoma | no | 0 | SD |
| Colorectal | yes | 1 | SD |
| Esophageal | no | 1 | PD |
| Dose Level 3 | |||
| Pancreas | no | 1 | N/A |
| Gallbladder | no | 0 | SD |
| Colorectal | no | 0 | PD |
| Ovarian | no | 4 | SD |
| Pancreas | yes | 1 | N/A |
| Pancreas | no | 1 | PD |
| Dose Level 4 | |||
| Pancreas | no | 0 | SD |
| Colorectal | yes | 1 | SD |
| Ovarian | no | 3 | PD |
| Bladder | no | 5 | PD |
| Cholangiocarcinoma | yes | 1 | SD |
| Esophageal | no | 2 | SD |
| Unknown | yes | 2 | SD |
| Cholangiocarcinoma | no | 2 | PD |
| Gastric | yes | 1 | SD |
| Breast | yes | 6 | PD |
| Cholangiocarcinoma | no | 1 | PD |
| Dose Level 5 | |||
| Pancreas | no | 1 | N/A |
| Cholangiocarcinoma | no | 2 | PR |
| Gastric | yes | 2 | CR |
| Cholangiocarcinoma | no | 0 | N/A |
Bolded text indicates DLT