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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Neurogastroenterol Motil. 2010 Mar 19;22(7):779–786. doi: 10.1111/j.1365-2982.2010.01489.x

Figure 3. GDNF-induced increase in ascending contraction and concomitant substance P release in rat colon.

Figure 3

Mucosal stroking in the caudad sensory compartment caused stimulus-dependent contraction of circular muscle (left panel) and release of substance P (right panel) in the orad motor compartment. GDNF (10 nM) caused a significant increase in both ascending contraction of circular muscle and concomitant substance P release. Basal release of substance P in the orad motor compartment was 2.8±0.4 fmol 100mg-min-1. Values are mean±SE of 4-5 experiments. Asterisks indicate significance of at least p<0.05.