Core evidence place in therapy summary for nilotinib in CML

Outcome measure	Evidence	Implications
Patient-oriented evidence
Safety and tolerability	Clear	Nilotinib is well tolerated
Disease-oriented evidence
Cytogenetic response	Substantial	Nilotinib produces major cytogenetic response in 31% (accelerated phase), 40% (blastic phase) and 57% (chronic phase) of patients resistant or intolerant to imatinib. 100% complete response has been achieved in newly diagnosed patients
Hematologic response	Substantial	Nilotinib produces complete hematologic response in 11% (blastic phase), 26% (accelerated phase), and 77% (chronic phase) of patients resistant or intolerant to imatinib