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. 2009 Dec 14;31(3):376–381. doi: 10.1093/carcin/bgp304

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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Fig. 1. — Histomorphological changes in mammary gland of female ACI rats exposed to 17β-estradiol for 6 and 12 weeks. (A) Mammary gland from untreated (control) ACI female rats (original magnification ×100); (B) Typical alveolar hyperplasia after 6 weeks of continuous E₂ treatment (original magnification ×100); (C) Typical hyperplasia showing alveolar lobule (AL) and a normal appearing intralobular duct (D) after 6 weeks of continuous E₂ treatment (original magnification ×400); (D) Typical hyperplasia after 12 weeks of continuous E₂ treatment (original magnification ×100; (E) Mammary gland hyperplasia with atypical (arrows) and typical (arrowheads) hyperplastic alveoli after 12 weeks of continuous E₂ treatment (original magnification ×100) and (F) Mammary gland hyperplasia with atypical hyperplastic ducts (arrows) line with variably sized epithelial cells (arrowheads). Duct lumen (L) contains intensely eosinophilic secretion; compare with normal appearing duct in panel C. Original magnification ×400.