Table IV.
Common (>5%) haplotypes and frequencies in block1a of DNMT1 or DNMT3B by ethnicity
| Gene | Haplotype | Allele | Frequency (%)b |
|||
| Non-Hispanic whites (n = 207) | Hispanics (n = 53) | Othersc (n = 18) | All (n = 278) | |||
| DNMT1 | H284 | CAGGGGTTTGCTGGCAAGATA | 51 | 56 | 37 | 51 |
| H200 | GGGATATCCGCTAACGTAATA | 39 | 28 | 19 | 36 | |
| H48 | GACATGCCCTGCGGTGTGGGG | 6 | 13 | 28 | 9 | |
| DNMT3B | H145 | AAGTTTTCGGCTCTATTCCTGGTAGCAGACATCAGTTCTCGAAA | 23 | 19 | 19 | 22 |
| H149 | AAGTTTTCGGCTCTATTCCTGGTAGCAGACATCAGTTCTCGGAA | 21 | 14 | 23 | 20 | |
| H91 | GGTCACTTGATCGCGCCTTCAGCATTGAGATGTGTCCGCTAGCG | 12 | 19 | 11 | 14 | |
| H70 | GAGCATCCGATCGCGCCTTCAACGTTGAGATGTGTCCGCTAGCA | 12 | 8 | 8 | 11 | |
| H49 | GGGCACTTGATCGCGCCTTCAGCATTGAGATGTGTCCGCTAGCG | 5 | 18 | 8 | 8 | |
| H11 | GGTCACTTAATCGCGCCTTCAACGTTGAGATGTGTCCGCTAGCA | 0 | 8 | 5 | 2 | |
a
Haplotype block boundaries were defined based on all subjects: DNMT1, block1 (rs11085587–rs8112895, 70 kb) and DNMT3B, block1 (rs6119279–rs8118663, 68 kb).
b
Population haplotype frequencies were estimated from the genotype data in non-Hispanic whites, Hispanics and others separately using Bayesian statistical method implemented in the program PHASE (version 2.1).
c
Others included Native American (n = 3), Black (n = 1), Asian (n = 4) and mixed ethnicity (n = 10).